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Баннер
Market
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Моксонитекс таблетки п/о плен. 0,4мг 28шт
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Моксонитекс таблетки п/о плен. 0,4мг 28шт

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Рецептурный препарат
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Нет в продаже у продавца
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Моксонитекс таб. п/о плен.
Моксонитекс таблетки п/о плен. 0,4мг 28шт
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Нет в продаже
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ЗдравСити - сервис заказа и выдачи лекарств
Магазин•4.8 166.3K оценок
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Инструкция
Артикул Market
103543876937
Бренд
Salutas Pharma
Количество штук в упаковке
28 шт.
Тип препарата
лекарственный препарат
Рецептурный препарат
да
Органы и системы
кровеносные сосуды, сердце
Назначение
артериальная гипертензия
Показания к применению
Артериальная гипертензия.
Противопоказания
- повышенная чувствительность к моксонидину или любому другому компоненту препарата;- ангионевротический отек в анамнезе;- наследственная непереносимость лактозы, дефицит лактазы или глюкозо- галактозная мальабсорбция;- выраженные нарушения ритма сердца (выраженная брадикардия (менее 50 уд/мин в покое), синдром слабости синусового узла или синоатриальная блокада, атриовентрикулярная блокада II и III степени);- острая и хроническая сердечная недостаточность;- тяжелая почечная недостаточность (КК <30 мл/мин, концентрация креатинина в сыворотке крови >160 мкмоль/л) и проведение гемодиализа;- одновременное применение с трициклическими антидепрессантами;- возраст до 18 лет;- период грудного вскармливания.
Состав
1 таблетка содержит:Действующее вещество: моксонидин 0,2 мг / 0,3 мг / 0,4 мг.Вспомогательные вещества: лактозы моногидрат, повидон-К-25, кросповидон, магния стеарат.Состав пленочной оболочки: титана диоксид, гипромеллоза, макрогол-400, краситель железа оксид красный.
Действующее вещество
Моксонидин
Способ применения и дозы
Внутрь, независимо от приема пищи.В большинстве случаев начальная доза препарата Моксонитекс составляет 0,2 мг в сутки. Максимальная разовая доза составляет 0,4 мг. Максимальная суточная доза, которую следует разделить на 2 приема, составляет 0,6 мг. Необходимо индивидуальная коррекция суточной дозы в зависимости от переносимости пациентом проводимой терапии.Коррекция дозы для пациентов с печеночной недостаточностью не требуется.Начальная доза для пациентов, находящихся на гемодиализе 0,2 мг в сутки.В случае необходимости и при хорошей переносимости суточная доза может быть увеличена до максимальной 0,4 мг в сутки.Пациентам с почечной недостаточностью рекомендуется осторожный подбор дозы, особенно в начале лечения. Начальная доза должна составлять 0,2 мг в сутки. В случае необходимости и при хорошей переносимости суточная доза препарата может быть увеличена максимум до 0,4 мг для пациентов с умеренной почечной недостаточностью (КК более 30 мл/мин, но не менее 60 мл/мин) 0,3 мг для пациентов с тяжело почечной недостаточностью (КК менее 30 мл/мин).
Побочные действия
По данным Всемирной организации здравоохранения (ВОЗ) побочные эффекты классифицированы в соответствии с их частотой развития следующим образом: часто (≥1/100, <1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000), включая отдельные сообщения.Со стороны сердечно-сосудистой системынечасто: брадикардия, выраженное снижение артериального давления (в том числе ортостатическая гипотензия).Со стороны центральной нервной системычасто: головокружение (вертиго), головная боль, сонливость, бессонница; нечасто: обморок, повышенная возбудимость.Со стороны органа слуха и лабиринтные нарушениянечасто: звон в ушах.Со стороны пищеварительной системыочень часто: сухость слизистой оболочки полости рта; часто: диарея, тошнота, рвота, диспепсия.Со стороны кожи и подкожных тканейчасто: кожный зуд, кожная сыпь; нечасто: ангионевротический отек (отек Квинке).Со стороны скелетно-мышечной и соединительной тканичасто: боль в спине; нечасто: боль в области шеи.Общие расстройства и нарушения в месте введениячасто: астения; нечасто: периферические отеки.
Фармакологическое действие
Селективный агонист имидазолиновых рецепторов, отвечающих за рефлекторный контроль над симпатической нервной системой (локализованной в вентро-латеральном отделе продолговатого мозга). Незначительно связывается с центральными альфа2-адренорецепторами, снижает систолическое и диастолическое артериальное давление (АД) при однократном и продолжительном применении.При длительном применении уменьшает гипертрофию миокарда левого желудочка, нивелирует признаки миокардиального фиброза, микроартериопатии, нормализует капиллярное кровоснабжение миокарда, снижает общее периферическое сосудистое сопротивление, легочное сосудистое сопротивление, в то время как сердечный выброс и частота сердечных сокращений (ЧСС) существенно не изменяются. На фоне лечения снижается активность норэпинефрина и эпинефрина, ренина, ангиотензина II в покое и при нагрузке, предсердного натрийуретического пептида (при нагрузке) и альдостерона плазмы крови.Уменьшает резистентность тканей к инсулину на 21% в сравнении с плацебо у пациентов с ожирением, и инсулинрезистентных пациентов с умеренной степенью тяжести артериальной гипертензии, стимулирует высвобождение гормона роста. Не влияет на обмен глюкозы и липидов.
Фармакологическая группа
гипотензивное средство центрального действия
Форма выпуска
таблетки
Способ применения/введения
пероральный
Условия хранения
Хранить при температуре не выше 25 °С.Хранить в недоступном для детей месте.
Передозировка
Имеются сообщения о нескольких случаях передозировки без летального исхода, когда одномоментно применялись дозы до 19,6 мг.Симптомы: головная боль, седативный эффект, сонливость, выраженное снижение АД, головокружение, астения, брадикардия, сухость во рту, рвота, усталость, боль в эпигастральной области, угнетение дыхания и нарушение сознания.Лечение:Специфического антидота не существует. В случае выраженного снижения АД может потребоваться восстановление объема циркулирующей крови за счет введения жидкости и допамина (инъекционного).Брадикардия может быть купирована атропином (инъекционное введение).В тяжелых случаях передозировки рекомендуется тщательно контролировать нарушения сознания и не допускать угнетения дыхания.Агонисты альфа-адренорецепторов могут уменьшать или устранять парадоксальное гипертензивные эффекты при передозировке моксонидина.
Применение при беременности и кормлении грудью
БеременностьКлинические данные о применении лекарственного препарата Моксонитекс у беременных отсутствуют.В ходе исследований на животных было установлено эмбриотоксическое действие препарата.Моксонитекс следует назначать беременным только после тщательной оценки соотношения риска и пользы, когда польза для матери превышает потенциальный риск для плода.Период грудного вскармливанияМоксонидин проникает в грудное молоко и поэтому не должен назначаться во время кормления грудью. При необходимости применения лекарственного препарата Моксонитекс в период лактации, грудное вскармливание необходимо прекратить.
Влияние на способность управлять транспортом и механизмами
Исследования влияния препарата на способность управлять автомобилем и другими механизмами не проводились. Имеются сообщения о сонливости и головокружении в период лечения моксонидином. Это следует учитывать при выполнении вышеуказанных действий.
Особые указания
С осторожностью: Атриовентрикулярная блокада I степени (риск развития брадикардии), заболевания коронарных артерий (в т.ч. ишемическая болезнь сердца, нестабильная стенокардия, ранний постинфарктный период), заболевания периферического кровообращения (в т.ч. перемежающаяся хромота, синдром Рейно), эпилепсия, болезнь Паркинсона, депрессия, глаукома; умеренная почечная недостаточность (КК 30-60 мл/мин, креатинин сыворотки 105-160 мкмоль/л), печеночная недостаточность; беременность. Во время лечения необходим регулярный контроль АД.В постмаркетинговом наблюдении зафиксированы случаи атриовентрикулярной блокады различной степени тяжести у пациентов, принимающих моксонидин. Связь между приемом препарата Моксонидин и замедлением атриовентрикулярной проводимости не может быть полностью исключена. Таким образом, при лечении пациентов с вероятной предрасположенностью к развитию атривентрикулярной блокады рекомендуется соблюдать осторожность.При назначении моксонидина пациентам с атривентрикулярной блокадой первой степени, следует проявлять особую осторожность, поскольку препарат может вызывать брадикардию. Моксонидин не должен использоваться у пациентов с атриовентрикулярной блокадой большей, чем первой степени.Следует проявлять особую осторожность при назначении моксонидина пациентам с тяжелой ишемической болезнью сердца или нестабильной стенокардией, в связи с ограниченным опытом применения препарата у данной группы пациентов.Поскольку моксонидин выводится в основном через почки, следует проявлять осторожность при назначении моксонидина пациентам с почечной недостаточностью, рекомендуется тщательное титрование дозы, особенно в начале терапии. Дозировка должно начинаться с 0,2 мг в день и может быть увеличена до 0,4 мг в день для пациентов с умеренной почечной недостаточностью (СКФ> 30 мл / мин, но <60 мл / мин) и до 0,3 мг в день для пациентов с тяжелой почечной недостаточностью (СКФ <30 мл / мин), если препарат показан и хорошо переносится.При необходимости отмены одновременно принимаемых бета- адреноблокаторов и препарата Моксонитекс сначала отменяют бета- адреноблокаторы и лишь через несколько дней Моксонитекс.В настоящее время нет подтверждения тому, что прекращение применения препарата Моксонитекс приводит к повышению АД. Однако не рекомендуется прекращать прием препарата Моксонитекс резко, вместо этого следует постепенно уменьшать дозу препарат в течение двух недель.У пациентов пожилого возраста может быть повышен риск развития сердечно-сосудистых осложнений вследствие применения гипотензивных препаратов, поэтому терапию препаратом Моксонитекс следует начинать с минимальной дозы.
Взаимодействие
Взаимное усиление действия при совместном назначении с др. гипотензивными лекарственными средствами.Бета-адреноблокаторы усиливают брадикардию, выраженность отрицательного ино- и дромотропного действия.Усиливает действие этанола, седативных средств, транквилизаторов и гипнотических препаратов.Толазолин дозозависимо уменьшает эффект действия Моксонидина.
Регистрационный номер
ЛСР-000084/10
Дата государственной регистрации
12.05.2021
Бренд
Salutas Pharma
Изготовитель
Salutas Pharma
Фасовщик
Salutas Pharma
Страна-производитель
Германия
Название препарата
Моксонитекс
Срок годности
23 мес.
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Артериальная гипертензия.
- повышенная чувствительность к моксонидину или любому другому компоненту препарата;
- ангионевротический отек в анамнезе;
- наследственная непереносимость лактозы, дефицит лактазы или глюкозо- галактозная мальабсорбция;
- выраженные нарушения ритма сердца (выраженная брадикардия (менее 50 уд/мин в покое), синдром слабости синусового узла или синоатриальная блокада, атриовентрикулярная блокада II и III степени);
- острая и хроническая сердечная недостаточность;
- тяжелая почечная недостаточность (КК <30 мл/мин, концентрация креатинина в сыворотке крови >160 мкмоль/л) и проведение гемодиализа;
- одновременное применение с трициклическими антидепрессантами;
- возраст до 18 лет;
- период грудного вскармливания.
Внутрь, независимо от приема пищи.
В большинстве случаев начальная доза препарата Моксонитекс составляет 0,2 мг в сутки. Максимальная разовая доза составляет 0,4 мг. Максимальная суточная доза, которую следует разделить на 2 приема, составляет 0,6 мг. Необходимо индивидуальная коррекция суточной дозы в зависимости от переносимости пациентом проводимой терапии.
Коррекция дозы для пациентов с печеночной недостаточностью не требуется.
Начальная доза для пациентов, находящихся на гемодиализе 0,2 мг в сутки.
В случае необходимости и при хорошей переносимости суточная доза может быть увеличена до максимальной 0,4 мг в сутки.
Пациентам с почечной недостаточностью рекомендуется осторожный подбор дозы, особенно в начале лечения. Начальная доза должна составлять 0,2 мг в сутки. В случае необходимости и при хорошей переносимости суточная доза препарата может быть увеличена максимум до 0,4 мг для пациентов с умеренной почечной недостаточностью (КК более 30 мл/мин, но не менее 60 мл/мин) 0,3 мг для пациентов с тяжело почечной недостаточностью (КК менее 30 мл/мин).

Отзывы

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22 оценки•7 отзывов
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Комментарий:Проблемы с покупкой, именно в таком варианте, именно в такой дозировке, именно от этого производителя. Через Яндекс без особых проблем нашёл!👍
Достоинства:цена,качество
Недостатки:нет
Комментарий:хорошие таблетки. очень сложно найти в аптеках. очень радует,что есть возможность через это приложение заказать.
Достоинства:Это хорошее лекарство как скорая помощь при гипертонии.
Комментарий:Доставка быстрая , цена нормальная, даже немного ниже, чем в аптеке.
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Войдите в аккаунтИ тогда откроется корзина, а цены на Market могут стать ниже
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