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Баннер
Market
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Теноф300 таблетки п/о плён. 300мг 30шт

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Артикул Market
103544342727
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Количество в упаковке
Рецептурный препарат
Тип препарата
Назначение
Инструкция
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Нет в продаже у продавца
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Теноф таб. п/о плен.
Теноф300 таблетки п/о плён. 300мг 30шт
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Магазин•4.8 162.9K оценок
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Инструкция
Артикул Market
103544342727
Бренд
Макиз-Фарма
Количество в упаковке
30 штук
Тип препарата
лекарственный препарат
Рецептурный препарат
да
Органы и системы
иммунная система
Назначение
ВИЧ-инфекция
Показания к применению
Лечение ВИЧ-1 инфекции в составе комбинированной антиретровирусной терапии у взрослых.
Противопоказания
Тенофовир противопоказан пациентам с гиперчувствительностью к любому компоненту препарата.С осторожностьюПочечная недостаточность с клиренсом креатинина менее 50 мл/мин, включая пациентов, находящихся на гемодиализе. При клиренсе креатинина менее 30 мл/мин применение препарата следует избегать; в том случае, если др. лечение недоступно, следует тщательно контролировать функцию почек и скорректировать интервал между введением препарата.
Состав
Тенофовира дизопроксил фумарат 300,0 мгВспомогательные вещества:- Кроскармеллоза натрия 40,0 мг- Лактозы моногидрат 153,33 мг- Целлюлоза микрокристаллическая 133,34 мг- Крахмал прежелатинизированный 33,33 мг- Магния стеарат 6,67 мг- Опадрай II светло-голубой (Двуокись титана - краситель; FD&C синий № 2, алюминиевый лак сертифицированный в соответствии с законом FD&C (FD&C Blue # 2 Aluminum Lake) - краситель; Гипромеллоза; Лактозы моногидрат (Lactose Monohydrate) - наполнитель; Триацетин (Triacetin)) 32,0 мг.
Действующее вещество
Тенофовир
Способ применения и дозы
Внутрь, не зависимо от приема пищи.Рекомендованная доза для лечения ВИЧ-1 инфекции: 300 мг 1 раз в день.Рекомендованный режим дозирования Тенофовира при почечной недостаточности: Клиренс креатинина 30-49 мл/мин: 300 мг каждые 48 ч. Клиренс креатинина 10-29 мл/мин: 300 мг каждые 72-96 ч.Гемодиализ: 300 мг каждые 7 дней после завершения сеанса диализа.Рекомендации по режиму дозирования у пациентов с клиренсом креатинина менее 10 мл/мин (без гемодиализа) отсутствуют.
Побочные действия
Ниже приведены нежелательные реакции с предполагаемой (возможной) связью с препаратом, которые перечислены по системно-органным классам в порядке убывания их выраженности, со следующей частотой: очень часто (>1/10) и часто (> 1/100, < 1/10), редко (> 1/10000, < 1/1000), очень редко (<1/10000), включая отдельные случаи.Нарушение метаболизма и питания: очень часто - гипофосфатемия.Со стороны нервной системы: очень часто - головокружение.Со стороны желудочно-кишечного тракта: очень часто - диарея, рвота, тошнота; часто - метеоризм. Комбинированная ретровирусная терапия ассоциировалась с такими метаболическими нарушениями, как гипертриглицеридемия, гиперхолестеринемия, инсулинорезистентность, гипергликемия и гиперлактатемия; перераспределением подкожной клетчатки (липодистрофия).Зарегистрированы случаи остеонекроза, особенно у пациентов с факторами риска или при длительной комбинированной противовирусной терапии. Частота неизвестна.Постмаркетинговый опытНарушение метаболизма и питания: редко - лактат-ацидоз, частота неизвестна - гипокалиемияРеспираторные, торакальные и медиастинальные нарушения: очень редко - диспноэ.Со стороны желудочно-кишечного тракта: редко - панкреатит.Со стороны гепатобилиарной системы: редко - повышение активности трансаминаз; очень редко - гепатит, частота неизвестна - стеатоз печени.Со стороны кожи и подкожных тканей: редко - сыпь.Со стороны опорно-двигательного аппарата: частота неизвестна - рабдомиолиз, остеомаляция, мышечная слабость, миопатия.Со стороны мочевыделительной системы: редко - острая почечная недостаточность, проксимальная ренальная тубулопатия (включая синдром Фанкони), гиперкреатининемия; очень редко - острый тубулярный некроз; частота неизвестна - нефрит (включая острый интерстициальный), нефрогенный несахарный диабет. Общие нарушения и изменения в месте введения: очень редко - астения.
Фармакологическое действие
Тенофовира дизопроксил фумарат in vivo превращается в тенофовир, аналог нуклеозидмонофосфата (нуклеотида) аденозина монофосфата. Тенофовир в последующем превращается в активный метаболит - тенофовира дифосфат. Тенофовир - нуклеотидный ингибитор обратной транскриптазы, обладает специфичной активностью по отношению к вирусу иммунодефицита человека (ВИЧ-1 и ВИЧ-2).
Фармакологическая группа
противовирусное средство
Форма выпуска
таблетки
Способ применения/введения
пероральный
Условия хранения
При температуре не выше 25 °С.Хранить в недоступном для детей месте.
Передозировка
В случае передозировки, пациент должен быть обследован для выявления возможных признаков интоксикации.В случае необходимости применяется стандартная поддерживающая терапия.Тенофовир эффективно удаляется гемодиализом с коэффициентом экстракции приблизительно 54%.После приёма 300 мг тенофовира, 4-часовая процедура гемодиализа приводит к удалению приблизительно 10% принятой дозы тенофовира.
Применение при беременности и кормлении грудью
При решении вопроса о применении препарата при беременности необходимо соотнести ожидаемый терапевтический эффект для матери с возможным риском применения препарата для плода.В связи с выявленными изменениями костной ткани на фоне приема препарата, и ограниченным опытом применения рекомендуется с осторожностью применять препарат во время беременности.Женщины детородного возраста во время лечения должны использовать надежные методы контрацепции. Кормящие матери: ВИЧ-инфицированные женщины должны быть проинструктированы об исключении грудного вскармливания.
Особые указания
Сообщалось о случаях развития лактат-ацидоза и выраженной гепатомегалии со стеатозом, включая летальные исходы, при использовании нуклеозидных аналогов;Впервые возникшая или прогрессирующая почечная недостаточность может привести к острой почечной недостаточности и синдрому Фанкони. Необходимо определение клиренса креатинина перед началом лечения тенофовиром. Необходим контроль клиренса креатинина и фосфора в сыворотке крови у пациентов с повышенным риском развития или прогрессирования почечной недостаточности. Необходимо избегать применения тенофовира одновременно или после недавнего лечения нефротоксичными препаратами.Необходимо исключать применение тенофовира одновременно с комбинированными противовирусными препаратами, в состав которых включен тенофовир (например, Трувада, Атрипла) и адефовира депивоксил. Тенофовир должен использоваться только как часть соответствующей антиретровирусной комбинированной терапии у ВИЧ-1 инфицированных пациентов.Снижение плотности костной ткани наблюдались у ВИЧ-инфицированных пациентов. Необходимо проводить контроль плотности костной ткани у пациентов с патологическим переломом в анамнезе, равно как и у пациентов, с повышенным риском остеопении. Перераспределение/накопление жировых отложений наблюдалось у ВИЧ-инфицированных пациентов, получающих комбинированную антиретровирусную терапию. Синдром восстановления иммунитета наблюдался у ВИЧ-инфицированных пациентов. Может потребоваться дальнейшая оценка и лечение.НефротоксичностьПри применении Тенофовира может развиться синдром Фанкони, сопровождающийся гипофосфатемией, гипоурикемией, протеинурией, нормогликемической глюкозурией; в некоторых случаях может развиться острая почечная недостаточность. На ранних стадиях течение может быть бессимптомным, либо сопровождаться миалгиями; в большинстве случаев симптомы исчезают при прекращении приема препарата. К факторам риска относятся низкую массу тела, и наличие заболевания почек на момент начала терапии. Частота развития нефротоксичных побочных эффектов крайне низкая у пациентов с исходно нормальной функцией почек.РезистенстностьЧувствительность снижена у пациентов с тремя и более мутациями резистентности к аналогам тимидина, включающими 41L и 210W. Чувствительность сохраняется при других сочетаниях тимидиновых мутаций и повышается при наличии мутации M184V.
Взаимодействие
Диданозин: увеличение концентрации диданозина при совместном применении; необходимо их применять с осторожностью и осуществлять контроль проявлений токсичности диданозина (например, панкреатит, нейропатия). Комбинация тенофовира с диданозином не рекомендуется; если это оправданно, необходимо рассмотреть возможность снижения дозы или прекращение терапии диданозином.Тенофовир комбинируют со сниженными дозами диданозина (например, пациентам с массой тела > 60 кг назначают диданозин 250 мг 1 раз в сутки; < 60 кг - 200 мг 1 раз в сутки). С другой стороны, такая низкодозовая комбинация, возможно, характеризуется низкой противовирусной активностью и недостаточным приростом количества С04-лимфоцитов, на что указывает высокая частота неэффективности терапии при применении этой комбинации с добавлением эфавиренза или невирапина.Атазанавир: снижение концентрации атазанавира при совместном применении и увеличение концентраций тенофовира. Необходимо применять тенофовир с атазанавиром только с дополнительным усилением действия последнего ритонавиром.Лопинавир/ритонавир: увеличение концентраций тенофовира при совместном применении.Дарунавир: увеличивает концентрацию тенофовира на 20-25 %. Препараты следует применять в стандартных дозах, при этом необходимо тщательно мониторировать нефротоксическое действие тенофовира.Тенофовир в основном выводится из организма через почки, совместное применение тенофовира с препаратами, которые уменьшают почечную функцию или сокращают/прекращают активную тубулярную секрецию, может увеличить сывороточную концентрацию тенофовира и/или увеличить концентрации других препаратов, выводимых через почки.Ганцикловир, валганцикловир и цидофовир конкурируют с тенофовиром за активную канальцевую секрецию почками, в результате чего повышается уровень тенофовира или одновременно применяемого лекарственного препарата; требуется настороженность в отношении возможных побочных эффектов. Нефротоксичные препараты могут также повышать концентрацию тенофовира в сыворотке крови.
Регистрационный номер
ЛСР-002600/10
Дата государственной регистрации
04.10.2019
Бренд
Макиз-Фарма
Изготовитель
Макиз-Фарма
Страна бренда
Индия
Страна-производитель
Россия
Название препарата
Теноф
Срок годности
720 дн.
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Лечение ВИЧ-1 инфекции в составе комбинированной антиретровирусной терапии у взрослых.
Тенофовир противопоказан пациентам с гиперчувствительностью к любому компоненту препарата.
С осторожностью
Почечная недостаточность с клиренсом креатинина менее 50 мл/мин, включая пациентов, находящихся на гемодиализе. При клиренсе креатинина менее 30 мл/мин применение препарата следует избегать; в том случае, если др. лечение недоступно, следует тщательно контролировать функцию почек и скорректировать интервал между введением препарата.
Внутрь, не зависимо от приема пищи.
Рекомендованная доза для лечения ВИЧ-1 инфекции: 300 мг 1 раз в день.
Рекомендованный режим дозирования Тенофовира при почечной недостаточности: Клиренс креатинина 30-49 мл/мин: 300 мг каждые 48 ч. Клиренс креатинина 10-29 мл/мин: 300 мг каждые 72-96 ч.
Гемодиализ: 300 мг каждые 7 дней после завершения сеанса диализа.
Рекомендации по режиму дозирования у пациентов с клиренсом креатинина менее 10 мл/мин (без гемодиализа) отсутствуют.

Отзывы

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31 оценка•8 отзывов
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Достоинства:Товар доктор прописал , так что не поспоришь
Недостатки:Побочные эффекты не обнаружены
Достоинства:Помогает, доступная цена
Недостатки:Есть вероятность разрушения всех суставов.
Комментарий:Доставили вовремя, товар соответствует описанию. Всё отлично 👍
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Войдите в аккаунтИ тогда откроется корзина, а цены на Market могут стать ниже
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