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Баннер
Market
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Толперизон+Лидокаин раствор для в/в и в/м введ. амп. 100мг/мл+2,5мг/мл 1мл 5шт
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Толперизон+Лидокаин раствор для в/в и в/м введ. амп. 100мг/мл+2,5мг/мл 1мл 5шт

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Рецептурный препарат
Тип препарата
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Нет в продаже у продавца
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Толперизон + Лидокаин р-р для в/м введ. амп.
Толперизон+Лидокаин раствор для в/в и в/м введ. амп. 100мг/мл+2,5мг/мл 1мл 5шт
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Нет в продаже
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ЗдравСити - сервис заказа и выдачи лекарств
Магазин•4.8 163.9K оценок
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Инструкция
Артикул Market
103544224603
Бренд
ХИМФАРМ
Объем
1 мл
Тип препарата
лекарственный препарат
Рецептурный препарат
да
Органы и системы
опорно-двигательная система
Назначение
спастичность скелетных мышц
Показания к применению
Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.Миофасциальный болевой синдром средней и тяжелой степени (в том числе мышечный спазм при дорсопатиях).
Противопоказания
Повышенная чувствительность к толперизону или химически сходному эперизону или к любому из компонентов препарата (включая лидокаин).Миастения gravis.Беременность и период грудного вскармливания.Дети и подростки до 18 лет.
Состав
Одна ампула (1 мл) содержит:действующие вещества: толперизона гидрохлорид - 100,00 мг, лидокаина гидрохлорид - 2,50 мг (в виде лидокаина гидрохлорида моногидрата 2,67 мг); вспомогательные вещества: метилпарагидроксибензоат, диэтиленгликоля моноэтиловый эфир, 0,1 М раствор хлористоводородной кислоты, вода для инъекций.
Действующее вещество
Толперизон+Лидокаин
Способ применения и дозы
Взрослым ежедневно по 1 мл (100 мг толперизона) 2 раза в сутки, внутримышечно или по 1 мл (100 мг толперизона) 1 раз в день внутривенно, медленно.Пациенты с почечной недостаточностьюОпыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.Пациенты с печеночной недостаточностьюОпыт применения толперизона у пациентов с печеночной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелом поражении печени назначение толперизона не рекомендуется.Применение у детейПрепарат Толперизон+Лидокаин не предназначен для применения у детей и подростков в возрасте до 18 лет.
Побочные действия
Профиль безопасности толперизона оценивался по данным постмаркетингового применения более чем у 12000 пациентов.В соответствии с этими данными, наиболее частыми были нарушения со стороны кожи и подкожных тканей, общие расстройства, нарушения со стороны нервной системы и желудочно-кишечного тракта.При постмаркетинговом применении реакции повышенной чувствительности составили 50-60% всех побочных реакций. Большинство побочных реакций не были серьезными и проходили самостоятельно. Жизнеугрожающие реакции повышенной чувствительности регистрировались очень редко.Побочные реакции приведены ниже в соответствии с классификацией MedDRA и частотой: нечасто (от ≥1/1000 до <1/100); редко (от ≥1/10000 до <1/1000); очень редко (<1/10000); частота неизвестна (невозможно оценить на основании имеющихся данных).Нарушения со стороны крови и лимфатической системыОчень редко: анемия, лимфаденопатия.Нарушения со стороны иммунной системыРедко: реакция повышенной чувствительности, анафилактическая реакция.Очень редко: анафилактический шок.Частота неизвестна: ангионевротический отек, включая отек лица, губ.Нарушения со стороны обмена веществ и питанияНечасто: анорексия.Очень редко: полидипсия.Нарушения психикиНечасто: бессонница, нарушения сна.Редко: снижение активности, депрессия.Очень редко: спутанность сознания.Нарушения со стороны нервной системыНечасто: головная боль, головокружение, сонливость.Редко: нарушение внимания, тремор, эпилепсия, гипестезия, парестезия, летаргия.Нарушения со стороны органа зренияРедко: нечеткость зрения.Нарушения со стороны органа слуха и лабиринтные нарушенияРедко: шум в ушах, вертиго.Нарушения со стороны сердцаРедко: стенокардия, тахикардия, ощущение сердцебиения.Очень редко: брадикардия.Нарушения со стороны сосудовНечасто: артериальная гипотензия.Редко: «приливы».Нарушения со стороны дыхательной системы, органов грудной клетки и средостенияРедко: одышка, носовое кровотечение, учащенное дыхание.Нарушения со стороны желудочно-кишечного трактаНечасто: дискомфорт в животе, диарея, сухость во рту, диспепсия, тошнота.Редко: боль в эпигастральной области, запор, метеоризм, рвота.Нарушения со стороны печени и желчевыводящих путейРедко: печеночная недостаточность легкой степени.Нарушения со стороны кожи и подкожных тканейРедко: аллергический дерматит, повышенная потливость, зуд, крапивница, сыпь.Нарушения со стороны почек и мочевыводящих путейРедко: энурез, протеинурия.Нарушения со стороны скелетно-мышечной и соединительной тканиНечасто: мышечная слабость, миалгия, боль в конечностях.Редко: дискомфорт в конечностях.Очень редко: остеопения.Общие расстройства и нарушения в месте введенияНечасто: астения, дискомфорт, усталость.Редко: чувство опьянения, чувство жара, раздражительность, жажда.Очень редко: дискомфорт в грудной клетке.Лабораторные и инструментальные данныеРедко: снижение артериального давления, гипербилирубинемия, изменение активности печеночных ферментов, тромбоцитопения, лейкоцитоз.Очень редко: увеличение концентрации креатинина в плазме крови.
Фармакологическое действие
Толперизона гидрохлорид - миорелаксант центрального действия. Оказывает мембраностабилизирующее, местноанестезирующее действие, тормозит проведение нервных импульсов в первичных афферентных волокнах и двигательных нейронах, что приводит к блокированию спинномозговых моно- и полисинаптических рефлексов. Предположительно, толперизон опосредует блокирование выделения медиаторов путем торможения поступления ионов кальция в синапсы. Тормозит проведение возбуждения по ретикулоспинальному пути в стволе головного мозга.Независимо от влияния на центральную нервную систему усиливает периферическое кровообращение. Это действие не связано с воздействием препарата на центральную нервную систему и может быть обусловлено слабым спазмолитическим и антиадренергическим действием толперизона.Лидокаина гидрохлорид обладает местноанестезирующим действием и при дозировании согласно инструкции системного действия не оказывает.
Фармакологическая группа
миорелаксант центрального действия
Форма выпуска
раствор для инъекций
Способ применения/введения
парентеральный
Условия хранения
В защищенном от света месте, при температуре от 8 до 15оС.Хранить в недоступном для детей месте.
Передозировка
Симптомы передозировки чаще всего включают: сонливость, желудочно-кишечные нарушения (тошнота, рвота, боль в эпигастрии), тахикардия, повышение артериального давления, брадикинезия и вертиго. В тяжелых случаях атаксия, тонико-клонические судороги, одышка и дыхательный паралич.Лечение: специфического антидота нет, рекомендована симптоматическая терапия.
Применение при беременности и кормлении грудью
БеременностьВ экспериментальных исследованиях на животных не выявлено тератогенного действия толперизона. По причине отсутствия значимых клинических данных толперизон не следует применять при беременности, за исключением случаев, когда ожидаемая польза определенно оправдывает потенциальный риск для плода.Период грудного вскармливанияПоскольку данные о выделении толперизона с грудным молоком отсутствуют, то его применение в период кормления грудью противопоказано.
Влияние на способность управлять транспортом и механизмами
Толперизон не оказывает влияния на способность управлять транспортными средствами и механизмами. Пациентам, у которых есть головокружение, сонливость, нарушение внимания, эпилепсия, нечеткость зрения или мышечная слабость во время применения толперизона, следует проконсультироваться с врачом.
Особые указания
Наиболее частыми нежелательными реакциями при применении толперизона в пострегистрационном периоде были реакции повышенной чувствительности. Их выраженность варьирует от легких кожных реакций до тяжелых системных реакций, включая анафилактический шок. Симптомами реакций повышенной чувствительности могут быть эритема, сыпь, крапивница, зуд, ангионевротический отек, тахикардия, артериальная гипотензия или одышка.Женщины и пациенты с повышенной чувствительностью к другим препаратам или с аллергией в анамнезе могут быть подвержены более высокому риску повышенной чувствительности к толперизону.В случае известной повышенной чувствительности к лидокаину при применении толперизона следует соблюдать повышенную осторожность из-за возможных перекрестных реакций.Пациентам следует быть внимательными в отношении любых симптомов повышенной чувствительности. При возникновении симптомов следует немедленно прекратить прием препарата и незамедлительно обратиться к врачу. Не следует повторно назначать толперизон после эпизода повышенной чувствительности к лекарственному препарату, его содержащему.Вспомогательные веществаПрепарат содержит метилпарагидроксибензоат, который может вызывать аллергические реакции (возможно, отсроченные) и, в исключительных случаях, бронхоспазм.С осторожностью:Препарат следует применять с осторожностью у женщин, пациентов с повышенной чувствительностью к другим препаратам или с аллергией в анамнезе (см. раздел «Особые указания»), у пациентов с почечной и печеночной недостаточность.
Взаимодействие
Исследования фармакокинетического лекарственного взаимодействия с маркерным субстратом изофермента CYP2D6 декстраметорфаном показали, что одновременное применение толперизона может повысить содержание в крови лекарственных средств, которые метаболизируются преимущественно изоферментом CYP2D6 (тиоридазин, толтеродин, венлафаксин, атомоксетин, дезипрамин, декстрометорфан, метопролол, небиволол, перфеназин).В лабораторных экспериментах на микросомах печени человека и гепатоцитах человека значительного ингибирования или индукции других изоферментов СУР (CYP2В6, CYP2С8, CYP2С9, CYP2С19, CYP1А2, CYP3А4) не обнаружено.В связи с разнообразием метаболических путей толперизона повышение экспозиции толперизона при одновременном применении субстратов изофермента CYP2D6 и/или других препаратов не ожидается.Несмотря на то, что толперизон является препаратом центрального действия, седативный эффект его очень низкий. При одновременном применении с другими миорелаксантами центрального действия дозу толперизона следует уменьшить.Толперизон усиливает действие нифлумовой кислоты, поэтому при одновременном применении следует рассмотреть уменьшение дозы нифлумовой кислоты или других нестероидных противовоспалительных препаратов (НПВП).
Регистрационный номер
ЛП-№(000762)-(РГ-RU)
Дата государственной регистрации
14.11.2022
Бренд
ХИМФАРМ
Изготовитель
Химфарм
Страна бренда
Россия
Страна-производитель
Россия
Срок годности
730 дн.
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Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.
Миофасциальный болевой синдром средней и тяжелой степени (в том числе мышечный спазм при дорсопатиях).
Повышенная чувствительность к толперизону или химически сходному эперизону или к любому из компонентов препарата (включая лидокаин).
Миастения gravis.
Беременность и период грудного вскармливания.
Дети и подростки до 18 лет.
Взрослым ежедневно по 1 мл (100 мг толперизона) 2 раза в сутки, внутримышечно или по 1 мл (100 мг толперизона) 1 раз в день внутривенно, медленно.
Пациенты с почечной недостаточностью
Опыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции почек. При тяжелом поражении почек назначение толперизона не рекомендуется.
Пациенты с печеночной недостаточностью
Опыт применения толперизона у пациентов с печеночной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелом поражении печени назначение толперизона не рекомендуется.
Применение у детей
Препарат Толперизон+Лидокаин не предназначен для применения у детей и подростков в возрасте до 18 лет.

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2 оценки•Нет отзывов
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Войдите в аккаунтИ тогда откроется корзина, а цены на Market могут стать ниже
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