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Баннер
Market
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Толперизон таб. п/о плен., 150 мг, 30 шт.
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Описание
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Толперизон таб. п/о плен., 150 мг, 30 шт.

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Артикул Market
103552899782
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Количество в упаковке
Рецептурный препарат
Тип препарата
Назначение
Инструкция
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Нет в продаже у продавца
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Толперизон таб. п/о плен.
Толперизон таб. п/о плен., 150 мг, 30 шт.
Задать вопрос
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Нет в продаже
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PolzaRU
PolzaRU
Магазин•4.8 108.9K оценок
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Инструкция
Артикул Market
103552899782
Бренд
Атолл
Количество в упаковке
30 штук
Тип препарата
лекарственный препарат
Рецептурный препарат
да
Органы и системы
опорно-двигательная система
Назначение
мышечные боли и спазмы, спастичность скелетных мышц
Показания к применению
Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.
Противопоказания
Миастения gravis.Детский возраст до 18-ти лет. Грудное вскармливание.Гиперчувствительность к любому из компонентов препаратаНепереносимость лактозы, недостаточность лактазы, глюкозо-галактозная мальабсорбция.
Состав
Одна таблетка 50 мг содержит:Активное вещество: толперизона гидрохлорид -50.00 мг;Вспомогательные вещества: целлюлоза микрокристаллическая - 72.60 мг; лактозы моногидрат (сахар молочный) - 45.10 мг; кроскармеллоза натрия - 7.60 мг: гипромеллоза - 1,90 мг; лимонной кислоты моногидрат - 1,50 мг; магния стеарат - 1,30 мг.Состав оболочки: гипромеллоза - 3,00 мг, макрогол - 4000 - 0.75 мг, титана диоксид - 1,25 мг.Одна таблетка 150 мг содержит:Активное вещество: толперизона гидрохлорид - 150.00 мг;Вспомогательные вещества: целлюлоза микрокристаллическая - 70.00 мг; лактозы моногидрат (сахар молочный) - 43,50 мг; кроскармеллоза натрия - 12,00 мг; гипромеллоза - 3,00 мг; лимонной кислоты моногидрат - 4,50 мг; магния стеарат - 2.00 мг.Состав оболочки: гипромеллоза - 4.80 мг, макрогол - 4000 - 1.20 мг, титана диоксид - 2.00 мг.
Действующее вещество
Толперизон
Способ применения и дозы
Внутрь, после еды, не разжевывая, не разламывая таблетку, запивая небольшим количеством воды. Биодоступноеть толперизона снижается при приеме натощак.По 50 мг 3 раза в день, постепенно повышая дозу до 150 мг 3 раза в день.Пациенты с почечной недостаточностьюОпыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона. с тщательным наблюдением за состоянием здоровья пациента и контролем функции ночек. При тяжелом поражении почек назначение толперизона не рекомендуется.Пациенты с печеночной недостаточностьюОпыт применения толперизона у пациентов с печеночной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона, с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелом поражении печени назначение толпиразона не рекомендуется.
Побочные действия
Профиль безопасности лекарственных препаратов толперизона подтверждается данными применения более чем у 12 000 пациентов. Согласно этим данным, наиболее часто описаны нарушения со стороны кожи и подкожных тканей, общие, неврологические и желудочно-кишечные расстройства.В пострегистрационныи период количество полученных сообщении о развитии реакции типе ^чувствительности. связанных с применением толперизона, составляло около 50- 60% от всех полученных сообщений. В большинстве случаев это были несерьезные пооочные реакции. Об угрожающих жизни аллергических реакциях сообщалось очень редко.Частота развития побочных эффектов классифицирована согласно рекомендациям Всемирной организации здравоохранения, характеризуется как: очень часто (>1/10). часто (>1/100. <1/10), нечасто (>1/1000. <1/100). редко (>1/10000. <1/1000). очень редко (<1/10000). включая единичные случаи, частота не известна (не может быть рассчитана на основании имеющихся данных).Со стороны крови и лимфатической системы: очень редко - анемия, лимфоаденопатия. Со стороны иммунной системы: редко - реакции гиперчувствительности*,анафилактические реакции; очень редко - анафилактический шок.Со стороны обмена веществ и питания: нечасто - анорексия; очень редко - полидипсия. Со стороны психики: нечасто - нарушение сна. бессонница; редко - слабость, депрессия; очень редко - спутанность сознания.Со стороны нервной системы: нечасто - головная боль, головокружение, сонливость; редко - синдром дефицита внимания, тремор, эпилепсия, парестезия, судороги, недомогание, летаргия.Со стороны органа зрения: редко - снижение остроты зрения.Со стороны органа слуха: редко - шум в ушах, вертиго.Со стороны сердечно-сосудистой системы: нечасто - артериальная гипотензия; редко стенокардия, тахикардия, ощущение сердцебиения, "приливы" крови к лицу; очень редко - брадикардия.Со стороны дыхательной системы: редко - одышка, носовое кровотечение, тахипноэ.Со стороны желудочно-кишечного тракта: нечасто - дискомфорт, диспепсия,диарея, сухость во рту, тошнота: редко -боли в эпигастрии, запор, метеоризм, рвота.Со стороны печени и желчевыводящих путей:редко - печеночная недостаточность средней степени.Со стороны кожи и подкожных тканей: редко - аллергический дерматит, гипергидроз, кожный зуд, кожная сыпь, крапивница.Со стороны скелетно-мышечной системы и соединительной ткани: нечасто - боль в мышцах, мышечная слабость, боль в конечностях; редко - дискомфорт в конечностях; очень редко - остеопения.Со стороны почек и мочевыводящих путей: редко - энурез, протеинурия.Общие расстройства: нечасто - астения, чувство усталости, недомогание; редко -ощущение опьянения, ощущение тепла, раздражительность, жажда; очень редко дискомфорт в грудной клетке.Лабораторные показатели: редко - гппербилирубинемия. нарушение функции печени, тромбоцитопения, лейкоцитоз; очень редко - гиперкреатининемия.*В рамках пострегистрационного мониторинга сообщалось об ангионевротическом отеке, включая отек лица и губ (частота неизвестна).
Фармакологическое действие
Толмеризон является миорелаксантом центрального действия. Механизм действияполностью не выяснен.Толперизон обладает высокой аффинностью к нервной ткани, достигая наибольших концентрации в стволе головною мозга, спинном мозге и переферической нервной системе. Основной эффект толперизона опосредован торможением спинальных рефлекторных дуг. Вероятно, этот эффект совместно с устранением облегчения проведения возбуждения по нисходящим путям обеспечивает терапевтическое воздействие толперизона. Химическая структура толперизона схожа со структурой лидокаина. Подобно лидокаину, он обладает мембраностабилизирующим действием и снижает электрическую возбудимость двигательных нейронов и первичных афферентных волокон. Толперизон дозозависимо тормозит активность потенциалзависимых натриевых каналов. Соответственно, снижается амплитуда и частота потенциала действия. Был доказан угнетающий эффект на потенциалзависимые каль щевые каналы. Предполагается, что в дополнение к его мембрапостабилизмрующему действию толперизон может также тормозить выброс медиатора. Толперизон обладает некоторыми слабыми свойствами а-адренергических антагонистов и антимускариновым действием.
Фармакологическая группа
миорелаксант центрального действия
Способ применения/введения
пероральный
Условия хранения
В защищенном от света месте при температуре нс выше 25 °С.Xpaнить в недоступном для детей месте.
Передозировка
Данные о передозировке толпернзоиа немногочисленны.В доклинических исследованиях острой токсичнос ти высокие дозы толпернзоиа вызывали атаксию, гонико-клонические судороги, одышку и дыхательный паралич.Толперизон не имеет специфического антидота. При передозировке рекомендуется симптоматическое и поддерживающее лечение.
Применение при беременности и кормлении грудью
В экспериментальных исследованиях на животных не выявлено тератогенного действия толиеризона. По причине отсутствия значимых клинических данных толперизои нс следует применять при беременности (особенно в 1 триместре), за исключением случаев, когда ожидаемая польза определенно оправдывает потенциальный риск для плода.Поскольку данные о выделении толперизона с грудным молоком отсутствуют, то его npименение в период кормления грудью противопоказано.
Влияние на способность управлять транспортом и механизмами
Толперизон не влияет на способность управлять транспортными средствами и механизмами.Пациенты, у которых наблюдалось головокружение, сонливость, нарушение внимания, судороги, нарушение зрения или мышечная слабость во время приема препарата, должны обратиться к врачу!
Особые указания
Наиболее частыми нежелательными реакциями являются реакции гиперчувствительности. Аллергические реакции проявляются от легких кожных до тяжелых системных, включая анафилактический шок. Симптомы аллергической реакции: покраснение, сыпь,крапивница, зуд, ангионевротический отек (отек Квинке), тахикардия, артериальная гипотензия и одышка.Пациенты женского иола с реакциями гиперчувствительности к другим препаратам или аллергическими реакциями в анамнезе подвержены более высокому риску.В случае известной гиперчувствительности к лидокаину при применении толперизона следует соблюдать повышенную осторожность из-за возможных перекрестных реакций.Пациентам следует быть внимательными в отношении любых симптомов гиперчувствительности. Если возникли симптомы, следует немедленно прекратить прием толперизона и немедленно обратиться к врачу. Не следует повторно назначать толперизоп после эпизода гиперчувствительности к лекарственному препарату, его содержащему.
Взаимодействие
Исследования фармакокинетического лекарственного взаимодействия с маркерным субстратом изофермента CYP2D6 декстрометорфаном показали, что одновременное применение толпернзоиа может повысить содержание в крови лекарственных средств, которые метаболизируются преимущественно изоферментом CYP2D6 (тиоридазон, толгеродин. венлафаксин, атомоксетин, дезипрамии, декстрометорфан, метопролол. небиволол, перфеназин).В лабораторных экспериментах на микросомах печени человека значительно ингибирования или индукции других изоферментов CYP(CYP2B6. CYP2C8, CYP2C9, CYP2C19. CYP1A2, CYP3A4) не обнаружено.В связи с разнообразием метаболических путей толперизона повышение экспозиции толпсризона при одновременном применении субстратов изофермента CYP2D6 и (или) других препаратов нс ожидается.Биодоступность толперизона снижается при приеме натощак.Несмотря на то, что толперизоп является препаратом центрального действия, седативный эффект его очень низкий. При одновременном применении с другими миорелаксантами цент зального действия дозу толперизона следует уменьшать.Толперизоп усиливает действие иифлумовой кислоты, поэтому при одновременном применении следует рассматривать уменьшение дозы иифлумовой кислоты или других пестероидных противовоспалительных средств (НПВС).
Регистрационный номер
ЛП-003131
Дата государственной регистрации
11.08.2020
Бренд
Атолл
Изготовитель
ОЗОН
Фасовщик
ОЗОН
Страна бренда
Россия
Страна-производитель
Россия
Название препарата
Толперизон
Срок годности
984 дн.
Симптоматическое лечение спастичности у взрослых, обусловленной инсультом.
Миастения gravis.
Детский возраст до 18-ти лет. Грудное вскармливание.
Гиперчувствительность к любому из компонентов препарата
Непереносимость лактозы, недостаточность лактазы, глюкозо-галактозная мальабсорбция.
Внутрь, после еды, не разжевывая, не разламывая таблетку, запивая небольшим количеством воды. Биодоступноеть толперизона снижается при приеме натощак.
По 50 мг 3 раза в день, постепенно повышая дозу до 150 мг 3 раза в день.
Пациенты с почечной недостаточностью
Опыт применения толперизона у пациентов с почечной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции почек средней степени необходимо проводить подбор дозы толперизона. с тщательным наблюдением за состоянием здоровья пациента и контролем функции ночек. При тяжелом поражении почек назначение толперизона не рекомендуется.
Пациенты с печеночной недостаточностью
Опыт применения толперизона у пациентов с печеночной недостаточностью ограничен, у данной категории пациентов чаще возникали нежелательные реакции. Поэтому у пациентов с нарушениями функции печени средней степени необходимо проводить подбор дозы толперизона, с тщательным наблюдением за состоянием здоровья пациента и контролем функции печени. При тяжелом поражении печени назначение толпиразона не рекомендуется.

Отзывы

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33 оценки•6 отзывов
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Достоинства:Работает
Недостатки:Нать противопоказания
Комментарий:Хороший отечественный производитель
Достоинства:Заявленные показания все подходят
Недостатки:Нет
Комментарий:"Озон" вообще, хороший производитель. И в данном случае, тоже
Комментарий:пользуюсь первый раз , пока не поняла .
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Войдите в аккаунтИ тогда откроется корзина, а цены на Market могут стать ниже
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